(2S)-2-[2-(3,5-Difluorophenyl)acetaMide]-N-[(7S)-5-Methyl-6-oxo-6,7-dihydro-5H-dibenzo[B,D]azepin-7-

Name	YO-01027
Synonyms	YO01027 YO-01027 DIBENZAZEPINE γ-Secretase Inhibitor XX Dibenzazepine (Deshydroxy LY 411575) (S)-2-(2-(3,5-Difluorophenyl)acetamido)-N-((S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7 (2S)-2-[2-(3,5-Difluorophenyl)acetaMide]-N-[(7S)-5-Methyl-6-oxo-6,7-dihydro-5H-dibenzo[B,D]azepin-7- N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide
CAS	209984-56-5
InChIKey	QSHGISMANBKLQL-OWJWWREXSA-N

Molecular Formula	C26H23F2N3O3
Molar Mass	463.48
Density	1.35
Melting Point	257-259?C
Boling Point	801.3±65.0 °C(Predicted)
Solubility	DMSO: soluble15mg/mL, clear
Appearance	White solid
Color	white to beige
pKa	12.76±0.20(Predicted)
Storage Condition	-20°C
In vitro study	YO-01027 interacts directly with the gamma-secretase complex and targets the N-terminal presenilin fragment. Administration of increasing concentrations of YO-01027 to cells expressing APPL or Notch resulted in progressive accumulation of APPL CTF fragments and complete dose-dependent reduction in NICD production. 10 μm YO-01027 reduces the number and activity of breast cancer stem cells (bcscs). A recent study showed that YO-01027 inhibited mucin MUC16 biosynthesis in undifferentiated cells before and during the fusion phase in a concentration-dependent manner via Notch inhibition, however, there is no such effect in cells at different stages after mitosis.
In vivo study	YO-01027, intraperitoneal injection at a dose of 1 mg/ml on the day of cell injection and the following 3 days significantly reduced MCF7 tumors, but had no effect on MDA-MB-231 tumors, compared with control mice (18-28 days). It also increases the latency. YO-01027 treatment of MCF7 tumors significantly reduced tumor volume. YO-01027 treatment of C57BL/6 mice inhibited epithelial cell proliferation and dose-dependently induced goblet cell differentiation in Intestinal Adenomas.

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany	3
HS Code	29337900

Last Update：2024-01-02 23:10:35

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CAS: 209984-56-5
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QQ: 3008007409

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(2S)-2-[2-(3,5-Difluorophenyl)acetaMide]-N-[(7S)-5-Methyl-6-oxo-6,7-dihydro-5H-dibenzo[B,D]azepin-7- Request for Quotation